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Who wins when comparing Armodafinil with Modafinil?
The names of these two ‘smart medications’ are very similar, but this is no guarantee that they have any of the same effects.
And yet, the distinctions between the two nootropics may be so slight as to be irrelevant.
Because of this, we are still left with a number of mysteries.
How does the efficacy of Modafinil compare to that of Armodafinil? Can we compare their durability? What about the potential adverse reactions to either? Is there a major difference in cost when comparing Waklert 150 with Modafinil? Could it be that the difference we’re fussing about is, at most, a few cents?
This comprehensive manual was designed specifically to address such concerns of Modvigil 200 also:
You’ll be an Armodafinil or Modafinil expert before you finish this article. Which nootropic supplement may work best for you.
Modafinil: What Is It?
Even though you probably already know about Modafinil, on the off chance that you don’t, we’ll give you a quick rundown of the smart medicine. You can buy modalert 200 by an order from online pharmacy Pillspalace.com.
Cephalon produced the prescription medicine modafinil before being acquired by Teva Pharmaceuticals; it is classified as a Schedule IV substance. In 1998, Modafinil (trade name: Provigil) was given approval by the Food and Drug Administration (FDA) to treat excessive daytime drowsiness caused by the following:
- Narcolepsy.
- Apnea of obstruction in the sleep cycle.
- Sleep disruption due to shift work.
Modalert 200 (Modafinil) has improved the lives of millions of individuals who suffer from sleep deprivation by allowing them to do daily tasks without becoming overtired.
However, Modafinil’s off-label usage as a cognitive enhancer has brought it far greater attention. Modafinil is considered a eugeroic because of its main impact of enhancing wakefulness and alertness.
However, in the Armodafinil vs. Modafinil debate, the opposite side must be presented in a fair and balanced manner…
Armodafinil: What Is It?
Cephalon also produced Armodafinil, which, like Modafinil, is a non-narcotic prescription medicine classified as Schedule IV. Nuvigil, a brand name of a drug called modafinil, was licensed by the FDA in 2007 to treat the same three medical disorders as modafinil.
Modafinil is officially a racemic molecule made up of two different enantiomers, the R-(-)-enantiomer and the S-(+)-enantiomer, of which the former is more often used.
Cephalon’s monopoly on producing and selling Modafinil ended when their patent on the medicine expired in 2015. Therefore, a new medicine was necessary for Cephalon to maintain profitable. In addition, they were fearful of losing their grip on the market share of the country’s overtired workers.
Intense testing revealed that the R-(-)-enantiomer of Modafinil had all the same qualities as the parent compound.
Does armodafinil metabolize into modafinil?
But unlike other drugs, it remains in your system for a longer period of time and may even be more powerful than the original dose.
Comparing Armodafinil and Modafinil
It makes little difference whether you’re comparing Nuvigil and Provigil or Artvigil 150 Armodafinil and Modafinil.
The similarities between the two medications outweigh the differences by a wide margin. The distinctions are of most interest to seasoned consumers of smart drugs, like ourselves, who are aiming to maximize the benefits of cognitive improvement.
Similarities
When put side by side, Provigil and Nuvigil have a lot in common. In reality, it will be quite difficult to distinguish between the two prescription treatments.
- Similar Drug Action Pharmacological Mechanism
Whether Modafinil or Armodafinil is more effective in promoting wakefulness is a topic of debate.
The two CNS stimulants seem to have identical mechanisms of action.
- Rather of causing widespread brain activation, they focus on specific areas:
By binding to the dopamine transporter, both armodafinil and modafinil are able to increase dopamine levels in certain brain areas and so inhibit reuptake of this neurotransmitter. Modafinil’s effects are unaffected by dopamine receptor antagonists like haloperidol or dopamine synthesis inhibitors like a-methyl-p-tyrosine.
Keep in mind that neither Armodafinil nor Modafinil have the same high risk of addiction and misuse as amphetamines or other classic stimulants.
- Dependent on Diet
The beginning effects of Modafinil or Armodafinil may be pushed out by 1–2 hours if you take the medication with meals, although the medications’ total bioavailability is unaffected.
In other words, when comparing Armodafinil with Modafinil, you should anticipate the benefits to “kick in” faster when you take either smart medication without meals.
- The Same Fatal t1/2
A drug’s half-life is the amount of time it takes for the drug’s concentration in the body to decrease by half. The terminal half-life of Armodafinil and Modafinil, respectively, is around the same, ranging from 13 to 15 hours:
Armodafinil’s effects wear off later in the day than those of modafinil’s, despite the two drugs having identical half-lives.
Armodafinil’s unique pharmacokinetic profile may lead to more daytime wakefulness in ES patients than modafinil.
In the “Differences” section, we’ll go into further detail about this discovery.
- How Well They Work to Treat the Disorders for Which They Were Designed:
When it comes to treating their respective illnesses, Modafinil and Armodafinil are incomparable to one another.
- Scheduled Dosing:
The recommended dose of Modafinil and the recommended dose of Armodafinil are different.
However, if you want to experience cognitive improvement from either medicine, you should take a dosage that is comparable to what is normally used to treat those conditions:
Recommended dosing for Provigil (i.e., Modafinil) in patients with obstructive sleep apnea and narcolepsy is 200 mg once day in the morning. Tablets of either 100mg or 200mg are available.
The recommended dosage of Nuvigil (i.e., Armodafinil) for treating sleep disorders including narcolepsy and sleep apnea is 150 mg once day, in the morning. It’s available in 50mg, 150mg, 200mg, and 250mg pills.
When treating shift work sleep disturbance, the prescribed dosage of either medication is administered just before each shift begins.
While both Armodafinil (250mg daily) and Modafinil (400mg daily) are generally well-tolerated at their maximum dosages, no extra advantages beyond those seen with the prescribed levels have been shown.
